Abstract
Sponsorship: Publication of this supplement was sponsored by the Medical Research Council Toxicology Unit (MRC-TU). All content was reviewed and approved by the Cell Death and Differentiation (CDD) Committee, which held full responsibility for the abstract selections.
Highlights
Sponsorship: Publication of this supplement was sponsored by the Medical Research Council Toxicology Unit (MRC-TU)
Treatment of BN175 cells with a novel TLR3 agonist riboxxol and SM potently kills BN175 in vitro suggesting that in vivo, riboxxol and SM could be applied systemically to treat recurring malignancies and prolong disease free survival
Summary
Selected abstracts from the 9th CDD MRC Conference: Genes vs Environment in Cancer. Sponsorship: Publication of this supplement was sponsored by the Medical Research Council Toxicology Unit (MRC-TU). By overlapping differential gene expression data and coexpression analyses in ovarian cancer patients, we identified a short-list of 10 genes whose expression is significantly correlated to TRAP1. Those include genes involved in drug metabolism and cholesterol biosynthesis. The latter has been found aberrantly dysregulated in several platinumresistant ovarian cancer cell lines in comparison to their matched sensitive counterparts. These studies candidate TRAP1 as promising drug target linking chemoresistance and metabolic addiction. Johnson[3], Moshe Oren[1], Yael Aylon[1]
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