Seizures and epilepsy in patients with a spontaneous intracerebral haematoma

Abstract

Background Seizures occur more frequently in patients with an intracerebral haematoma (ICH) than in those with a cerebral infarct. However, the risk factors for seizures in association with an ICH are less well known. Purpose The characteristics of medically treated patients with spontaneous ICHs, who developed seizures, were retrospectively compared to those who did not. Patients Fourteen patients were admitted to the Stroke Unit during 2004–2006 for seizures related to an ICH. Their characteristics were compared to those of 51 patients admitted during 2002–2004 for an ICH without subsequent seizures. Results Early-onset seizures, occurring within 48 h of stroke onset, were observed in six patients with ICH related epileptic spells (42.9%). Late-onset ones occurred in eight patients, on average 8 months after the ICH. A focal onset of the seizures was documented in 75.7% of cases. Status epilepticus was observed in 21.4% of the patients. The seizures recurred in only 28.6% of the patients. Lobar haematomas were present in 78.6% of the seizure group, compared to 21.4% in the control group ( P = 0.008). In the former group a frontal lobe involvement was present in 57.1% compared to 9.8% in the latter group ( P < 0.001). On the post-ictal EEG, intermittent rhythmic delta activities were observed in 28.6% and periodic lateralized epileptic discharges in 21.4% of the seizure patients. Conclusions Seizures are more prone to occur in patients with frontal lobar haematomas. EEG can be helpful for the diagnosis of seizures in approximately 50% of the cases.