Abstract
The effects of selective lesioning of brain catecholamine—or serotonin-containing neurones on electroshock seizure thresholds and anticonvulsant activity of diphenylhydantoin, phenobarbital and carbamazepine were studied in rats. An intraventricular injection of 6-hydroxydopamine, which markedly decreased brain catecholamine concentrations, lowered seizure thresholds and decreased the anticonvulsant effect of the antiepileptic compounds under study. Pretreatment with desipramine, which protected noradrenergic neurones from the neurotoxic action of 6-hydroxydopamine, did not significantly affect seizure thresholds and drug activity with respect to controls. Raphe lesions, which selectively decreased brain serotonin, also did not significantly modify seizure thresholds or drug anticonvulsant activity. The findings are compatible with the hypothesis that brain catecholamines, particularly noradrenaline, play a role in the control of seizure susceptibility as well as in the anticonvulsant activity of diphenylhydantoin, phenobarbital and carbamazepine in the rat.
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