Abstract
BackgroundConn’s syndrome is a curable condition if identified properly. It is characterized by autonomous secretion of aldosterone from the adrenal gland cortex. Its morbidity is related to the increased risk of cardiovascular diseases.Case presentationWe report the case of a 48-year-old man of African descent presenting with generalized tonic-clonic seizure and coma secondary to hypertensive encephalopathy. A biochemical evaluation revealed a very high aldosterone level and an undetectable renin level, both are compatible with primary aldosteronism. The presentation of the following confirms the diagnosis of primary aldosteronism: spontaneous hypokalemia, an undetectable renin level, and a high aldosterone level. Abdominal computed tomography revealed a left adrenal adenoma. Adrenal venous sampling confirmed lateralization of aldosterone excretion from the left adrenal gland. Our patient underwent left laparoscopic adrenalectomy that confirmed a left functional adrenal adenoma. After 12 months of follow up, his hypertension was controlled on only one antihypertensive drug which was down from four drugs preoperatively.ConclusionConn’s syndrome, in this case, was complicated by coma secondary to seizure. Adrenalectomy normalized the hypokalemia and improved resistant hypertension. Potassium supplementation and several antihypertensives were discontinued as our patient became normokalemic and normotensive on one antihypertensive agent.
Highlights
Conn’s syndrome is a curable condition if identified properly
Further history revealed no recreational drugs exposure, no tobacco smoking, and no alcohol consumption; he had no previous history of epilepsy or head trauma. He was not known to have any cardiac comorbidities such as ischemic heart disease or congestive heart failure. His past medical history is remarkable for resistant hypertension; he was on four anti-hypertensive agents but was non-compliant in taking them: atenolol 50 mg, spironolactone 100 mg, amlodipine 10 mg, and valsartan 160 mg
We report a case of Primary aldosteronism (PA) due to unilateral adrenal adenoma that was complicated by seizure and coma secondary to hypertensive encephalopathy
Summary
Conn’s syndrome, in this case, was complicated by coma secondary to seizure. Adrenalectomy normalized the hypokalemia and improved resistant hypertension. Potassium supplementation and several antihypertensives were discontinued as our patient became normokalemic and normotensive on one antihypertensive agent
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