Abstract
BackgroundWhile video-assisted thoracic surgery lobectomy has been widely accepted for the treatment of non–small cell lung cancer, the debate over video-assisted thoracic surgery segmentectomy still remains. This study compared the clinical outcomes using the two procedures for stage I non–small cell lung cancer patients.MethodsRetrospective review was conducted on patients who underwent video-assisted thoracic surgery segmentectomy or lobectomy for clinical stage I non–small cell lung cancer at Shanghai Chest Hospital between November 2009 and May 2012. Video-assisted thoracic surgery segmentectomy was performed on 36 patients and video-assisted thoracic surgery lobectomy on 138 patients. Comparisons between the 2 groups were performed in patient demographic and clinical characteristics, intraoperative parameters and oncology outcomes.ResultsMean volume of chest tube drainage after operation was smaller for segmentectomy than for lobectomy (1021 ml vs. 1328 ml, P=0.036). Other parameters analysis including blood loss, operation time, chest tube duration and length of hospital stay favors the segmentectomy group numerically without significance. There was no significant difference in distributions in both intra and post operative complications. There was one peri-operative mortality from segmentectomy group and all other patients are alive with a median follow up of 327 days. There were 1 (2.8%) locoregional recurrence after segmentectomy and 6 recurrences (4.4%) after lobectomy (P=1.00). Multivariate survival analysis revealed no significant difference in recurrence-free survivals between the two groups. Two patients successfully underwent bilateral segmentectomies and are free of disease.ConclusionsFor patients with stage I non–small cell lung cancer, video-assisted thoracic surgery segmentectomy offers a safe and equally effective option and can be applied to complicated operation such as bilateral segmentectomy.
Highlights
While video-assisted thoracic surgery lobectomy has been widely accepted for the treatment of non–small cell lung cancer, the debate over video-assisted thoracic surgery segmentectomy still remains
Video-assisted thoracic surgery (VATS) segmentectomy was performed on 36 patients, and VATS lobectomy on 138 patients
The histopathology distribution was different between segmentectomy and lobectomy (P = 0.031), with adenocarcinoma (ADC) and bronchiolo-alveolar carcinoma (BAC) accounting for 61.1% and 25.0% in the segmentectomy group, while in lobectomy group, the percent of ADC was predominantly higher (80.4%)
Summary
While video-assisted thoracic surgery lobectomy has been widely accepted for the treatment of non–small cell lung cancer, the debate over video-assisted thoracic surgery segmentectomy still remains. This study compared the clinical outcomes using the two procedures for stage I non–small cell lung cancer patients. Non-small cell lung cancer (NSCLC) represents approximately 80% of all lung cancers [1] and the traditional treatment for stage I NSCLC is lobectomy. In 1973, Jensik et al [2] published a study suggesting that segmental resection was equivalent to lobectomy and represented an adequate operation for stage I NSCLC. Video-assisted thoracic surgery (VATS) has been introduced in a variety of thoracic operations, including small-sized lung cancer. C-VATS, the pure video-based operation was the procedure we used in our studies
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