Abstract
Complex background, critical noise and fuzzy boundary made the performance of the available cell image segmentation methods disappointing. Thus, a new method that can locate and detect nucleus effectively was proposed in this paper. A coarse-to-fine segmentation strategy was adopted to extract the edge of nucleus gradually. First, by using C-means clustering algorithm, the image was divided to three parts: nucleus, cytoplasm and cell intercellular substance. Second, the center of cell was located by calculating the circularity of Canny edge image. Finally, a reformed level set evolution was introduced to extract the edge of nucleus. The experimental results show that, nucleus can be located accurately; even if the cell image has a complex background and is disturbed by much stuff. Moreover, the edge of nucleus extracted by this method has a higher accuracy.
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