Segmentation analyses for assessing cortical SUVr in Alzheimer's disease using the novel PET amyloid tracer 18F-NAV4694

Abstract

group differences were detected through two sample t-test. No significant difference was detected in ventral attention network between MCI and healthy elderly. While in dorsal attention network, significant difference was detected between MCI and healthy elderly. While taking comparison to healthy elderly, decreased functional connectivity to left IPL was observed in right cerebellar lobule VIIa Crus II, in addition to bilateral frontal cortex, right precuneus, right temporal cortex. And increased functional connectivity to left IPL was observed in right cerebellar vermis VI, right cerebellar lobule VI, right cerebellar VIIa Crus I, left cerebellar lobule VI, in additon to bilateral precuneus. Conclusions: TPJ and IPL is the core of ventral and dorsal attention network. Changes of functional activity were observed in dorsal attention network in MCI. And cerebellum may play an important role in this process.