Abstract
BackgroundIn patients with colorectal cancer liver metastases (CRLM), right portal vein embolisation (RPVE) is used to increase the volume of the future remnant liver (FRL) before major hepatic resection. It is not established whether embolisation of segment 4 in addition RPVE (RPVE + 4) induces greater hypertrophy of the FRL. Limitations of prior studies include heterogenous populations and use of hypertrophy metrics sensitive to baseline variables.MethodsFrom 2010 to 2015, consecutive patients undergoing RPVE or RPVE + 4 for CRLM, who had not undergone prior major hepatic resection and in whom imaging was available, were included in a retrospective study. Data were extracted from hospital electronic records. Volumetric assessments of segments 2–3 were made on cross-sectional imaging before and after embolisation and corrected for standardised liver volume.ResultsNinety-nine patients underwent PVE, and 60 met the inclusion criteria. Thirty-eight patients underwent RPVE, and 22 underwent RPVE + 4. Forty-five patients had undergone median 6 cycles of prior chemotherapy. Eighteen patients had FRL metastases at PVE, and 16 had undergone subsegmental metastasectomy in the FRL. Assessments of the degree of hypertrophy (DH) of segments 2/3 were made at median 35 (interquartile range 30–49) days after PVE. RPVE + 4 resulted in a significantly greater increase in DH than RPVE (7.7 ± 1.8% vs 11.3 ± 2.6%, p = 0.011). No confounding association between baseline variables and the decision to undertake RPVE or RPVE + 4 was identified. Median survival was 2.4 years and was not influenced by segment 4 embolisation.ConclusionRPVE + 4 results in greater DH of segments 2/3 than RPVE in people with CLRM.
Highlights
An increase in volume of non-embolised segments of liver after embolisation of segmental branches of the portal vein was initially described in the mid-1980s [1]
Background In patients with colorectal cancer liver metastases (CRLM), right portal vein embolisation (RPVE) is used to increase the volume of the future remnant liver (FRL) before major hepatic resection. It is not established whether embolisation of segment 4 in addition RPVE (RPVE ? 4) induces greater hypertrophy of the FRL
The degree of hypertrophy (DH) of segments 2/3 was calculated by subtracting the volume of these segments before embolisation from their volume on the last scan before major hepatic resection (Vpost- Vpre) and correcting for standardised liver volume. sLV is derived as a function of body surface area (BSA)
Summary
An increase in volume of non-embolised segments of liver after embolisation of segmental branches of the portal vein was initially described in the mid-1980s [1]. In patients in whom the FRL will be small, portal vein embolisation (PVE) increases FRL volume [6,7,8] and function [9,10,11]. Tumours in non-embolised segments of liver may progress more rapidly after PVE [14, 15], of importance for disease in segment 4 given its proximity to the resection margin. The degree of hypertrophy (DH) of segments 2/3 was calculated by subtracting the volume of these segments before embolisation from their volume on the last scan before major hepatic resection (Vpost- Vpre) and correcting for standardised liver volume (sLV). BSA was determined using the Mosteller method [24]
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