Abstract
Oligo(ε-caprolactone) and oligolactide were synthesized via ring-opening polymerization of cyclic esters in the presence of creatinine as initiators. Thus obtained oligomers were successfully used in the synthesis of novel polyurethane conjugates of norfloxacin. The structures of the polymers and conjugates were elucidated by means of MALDI-TOF MS, NMR and IR studies.
Highlights
Pharmacy is one of the most important areas of applications of polymers
We describe the synthesis of a series of linear polyurethane conjugates of norfloxacin
The aim was to obtain a low-molecular weight polyesters, terminated at both sides by hydroxyl groups, which can be subsequently used as segments in polyurethane conjugates
Summary
Pharmacy is one of the most important areas of applications of polymers. They are used as active macromolecular pharmaceutical substances, blood substitutes, auxiliary materials and excipients, reagents for synthesis of macromolecular prodrugs, in polymeric drug delivery systems, therapeutic systems, etc. [1,2,3,4,5,6,7,8,9,10,11]. Pharmacy is one of the most important areas of applications of polymers They are used as active macromolecular pharmaceutical substances, blood substitutes, auxiliary materials and excipients, reagents for synthesis of macromolecular prodrugs, in polymeric drug delivery systems, therapeutic systems, etc. Polyesters, polyethers and polycarbonates are usually used as oligomers They were successfully synthesized by ring opening polymerization of cyclic monomers in the presence of cationic or anionic initiators, as well as coordinating and enzymatic catalysts [19,20,21,22,23,24,25,26,27,28,29,30,31]. The anticancer action of norfloxacin is supposed to be improved by anchoring the drug, using a chemical linkage, to biodegradable oligomers Such delivery systems can transport the drug molecules more efficiently and . We believe that the obtained polyurethanes can find practical applications as effective drug delivery systems transporting active substances to specific body locations at the required rate
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
