Abstract
In this study, the ageing-specific expression genes of the murine cerebrum were investigated by employing differential-display reverse transcription polymerase chain reaction (DDRT-PCR) in three senescence-accelerated mouse (SAM) strains: SAMP8/Ta, SAMP10/Ta and SAMR1TA. In the comparison of gene expression profile in different strain mice, 16 differential fragments have been detected, 3, 6 and 7 of them belong to SAMP10/Ta, SAMP8/Ta and SAMR1TA, respectively. Sequencing data indicated that those fragments are homologous with heat shock protein cognate protein 70, ATP-dependent mitochondrial RNA helicase, Dleu2 mRNA, Mouse DNA sequence from clone RP23-334C3 on chromosome X, ubiquinol-cytochrome c reductase complex (7.2 kDa), 60S ribosomal protein L21, FIS, phenylalkylamine Ca 2+ antagonist (emopamil) binding protein, fucosyltransferase 9, glial cell line derived neurotrophic factor family receptor alpha 1, endonuclease/reverse transcriptase, PER1 interacting protein of the suprachiamatic nucleus homolog, centrosomal protein CG-NAP, ferritin heavy chain gene, NID-2 gene, and prkdc gene for DNA-dependent protein kinase catalytic subunit.
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