Abstract
In this issue of Structure, Guan etal. (2017) describe cryo-EM mapping of human papillomavirus 16 (HPV16) capsids that propose locations for L2 and heparin binding sites. The high resolution of the modern cryo-EM methods (in this case down to 4.3Å) opens great opportunities to probe conformational changes that take place during virus-receptor binding.
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