Sedum freckle capsule combined with hydroquinone cream phonophoresis in the treatment of chloasma

Abstract

Objective To evaluate the clinical efficacy of Sedum freckle capsule combined with hydroquinone cream phonophoresis in the treatment of chloasma. Methods A total of 180 patients with chloasma were recruited into two groups according to the random number table, 100 in the treatment group and 80 in the control group. The patients in the control group were treated with 2% hydroquinone cream phonophoresis, and those in the treatment group received 2% hydroquinone cream phonophoresis and Sedum freckle capsules, both for 2 months. The symptom and lesion score were used to evaluate the clinical efficacy. Results The cure rates were 81.00% in the treatment group and 67.50% (χ2=4.320, P=0.038) in the control group at the end of treatment, 92.0% and 76.3% (χ2=5.538, P=0.019) at 2 months follow-up. The total lesion scores at the end of treatment and at 2 months follow-up were significantly lower than before the treatment in the treatment group (1.61 ± 0.84 and 1.30 ± 0.85 vs. 3.48 ± 1.02; t=14.152, 16.419, all P<0.01) and also in the control group (2.04 ± 0.61 and 2.03 ± 0.51 vs. 3.45 ± 1.09; t=10.097, 10.554, all P<0.01). The total lesion score at the end of treatment and at 2 months follow-up were significantly lower than in the treatment group was significantly decreased than the control group (t=3.839, 6.767; all P<0.01). Conclusion Sedum freckle capsule combined with hydroquinone cream phonophoresis could effectively treat patients with chloasma. Key words: Chloasma; Hydroquinones; Phonophoresis; Sedum freckle capsule