Abstract
Cells isolated from adult and fetal rat liver and ascites hepatoma were separated into distinct populations by velocity sedimentation at unit gravity. Normal adult liver ceils sediment with modal velocities ranging from 5 to 50 mm/h. Volume analysis using a Coulter-type counter demonstrated that the separation was based primarily on cell size. Appreciable differences were observed in the sedimentation velocity distribution of cells isolated from different normal lobes or regenerating liver. Most fetal rat liver cells sediment with velocities inferior to 12 mm/h. Ascites (Novikoff) hepatoma cells present a velocity distribution more similar to that of fetal than to normal adult liver cells. The results are discussed in terms of cell-size changes associated with liver maturation, regeneration or transformation.
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