Abstract
Background: Emerging work is starting to investigate the cumulative effects of moderate-to-vigorous physical activity (MVPA), sedentary behavior and cardiorespiratory fitness on health. The objective of this study was to examine the cumulative and independent associations of MVPA, sedentary behavior and cardiorespiratory fitness on leukocyte telomere length (LTL). Methods: Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were used (N = 1868 adults 20+ years); analyzed in 2016. Sedentary behavior and MVPA were subjectively assessed with cardiorespiratory fitness determined from a submaximal treadmill-based test; participants were classified as above or below the median values for each of these three parameters. A blood sample was obtained from each participant to assess LTL via quantitative polymerase chain reaction, with participants grouped into LTL tertiles. Results: Participants who engaged in higher MVPA, sat less and had higher cardiorespiratory fitness had an increased odds (ranging from 85% to 105%) of being in LTL tertile 3 (vs. 1). In an extended adjusted multinomial logistic regression model, only MVPA was positively associated with LTL (odds ration [OR] = 1.37; 95% CI: 0.99-1.90; P = 0.05). Conclusion: All three behavior characteristics, but particularly MVPA, may be important in preserving LTLs.
Highlights
Telomeres are nucleoprotein structures that promote stability of chromosomes by capping their ends.[1]
Using data from the 20032006 National Health and Nutrition Examination Survey (NHANES), the author computed the correlation between this self-report screen-based sedentary behavior item and identical categories (h/d) of accelerometer-determined sedentary behavior; a weak statistically significant association (r = 0.10, P < 0.0001) was observed, which is not unexpected as this self-report screen-based sedentary item only assessed non-occupational sedentary behavior, whereas accelerometry assesses overall daily sedentary behavior. This observed correlation is within the range (r = -0.19 to 0.80) of a review paper documenting the concurrent validity of television viewing time and other non-occupational sedentary behaviors[20]; notably, only 3 of the evaluated studies from this review examined the validity of self-reported television viewing time and other non-occupational sedentary behaviors
The main finding of the present study was that adults with all three behavioral characteristics had the longest leukocyte telomere length (LTL)
Summary
Telomeres are nucleoprotein structures that promote stability of chromosomes by capping their ends.[1]. Emerging work is starting to investigate the cumulative effects of moderateto-vigorous physical activity (MVPA), sedentary behavior and cardiorespiratory fitness on health. The objective of this study was to examine the cumulative and independent associations of MVPA, sedentary behavior and cardiorespiratory fitness on leukocyte telomere length (LTL). Sedentary behavior and MVPA were subjectively assessed with cardiorespiratory fitness determined from a submaximal treadmill-based test; participants were classified as above or below the median values for each of these three parameters. Results: Participants who engaged in higher MVPA, sat less and had higher cardiorespiratory fitness had an increased odds (ranging from 85% to 105%) of being in LTL tertile 3 (vs 1). In an extended adjusted multinomial logistic regression model, only MVPA was positively associated with LTL (odds ration [OR] = 1.37; 95% CI: 0.99-1.90; P = 0.05). Conclusion: All three behavior characteristics, but MVPA, may be important in preserving LTLs
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