Abstract
ObjectiveThe primary aim of this study was to determine whether time spent in sedentary behaviors (SED) was associated with 2-hour glucose and insulin resistance in adults with abdominal obesity. We also examined the association between light physical activity (LPA) and sporadic (accumulated in bouts <10 minutes in duration) moderate-to-vigorous physical activity (MVPA) with glucose metabolism.MethodsParticipants were 135 inactive, abdominally obese adults recruited from Kingston, Canada. SED and physical activity were determined by accelerometry over 7 days and summarized as SED (accelerometer counts/min <100), LPA (counts/min 100–1951), and MVPA (counts/min ≥1952). A 75 g oral glucose tolerance test was used to ascertain 2-hour glucose; the homeostasis model of assessment was used to determine insulin resistance (HOMA-IR); lipid, lipoproteins and blood pressure were determined using standard protocols. Secondary analyses considered the association between SED and physical activity with other cardiometabolic risk factors.ResultsParticipants spent 627.2±82.9 min/d in SED, 289.0±91.7 min/d in LPA and 19.2±13.5 min/d in MVPA. Neither SED nor the physical activity variables were associated with 2-hour glucose or HOMA-IR (p>0.05). In secondary analyses, SED was not associated with any cardiometabolic risk factor (p>0.1); with the exception of blood pressure (p<0.05), LPA was not associated with any cardiometabolic risk factor (p>0.1); and MVPA was independently associated with total cholesterol and triglycerides (p<0.05).ConclusionsObjectively measured SED was not associated with 2-hr glucose or HOMA-IR. Our findings also suggest that the accumulation of LPA and sporadic MVPA is not associated with glucose metabolism in adults with abdominal obesity.
Highlights
Sedentary behaviors (SED), which include activities such as television viewing or computer screen time, have gained widespread interest due to observations suggesting they have a negative impact on a variety of health outcomes [1,2,3]
All participants were confirmed as inactive according to the consensus recommendation that adults accumulate 30 minutes of daily moderate-tovigorous physical activity (MVPA) in bouts of $10 minutes, approximately 5 hours of light physical activity (LPA) and 20 minutes of sporadic MVPA were accumulated daily (Table 1)
Neither SED nor the physical activity variables were associated with 2-hour glucose or HOMA-IR (p.0.05)
Summary
Sedentary behaviors (SED), which include activities such as television viewing or computer screen time, have gained widespread interest due to observations suggesting they have a negative impact on a variety of health outcomes [1,2,3]. Evidence from Healy et al [4,5] indicates that, independent of moderate-tovigorous physical activity (MVPA), time spent in SED is positively associated with 2-hour glucose, waist circumference, and clustered metabolic risk in middle-aged adults. Others [7,8] observe a univariate association of SED with select cardiometabolic risk factors this association is not independent of MVPA or total activity. Whether time spent SED explains cardiometabolic risk beyond MVPA has important public health implications and we sought to clarify the relationships between SED, LPA, and MVPA with 2-hour glucose and insulin resistance in a population of inactive adults with abdominal obesity. Secondary analyses examined the association between SED, LPA, MVPA and other common cardiometabolic risk factors (triglycerides, total cholesterol, high-density lipoproteins, and blood pressure)
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