Abstract
BackgroundSedentary behavior is ubiquitous in modern adults' daily lives and it has been suggested to be associated with incident cancer. However, the results have been inconsistent. In this study, we performed a systematic review and meta-analysis of prospective cohort studies to clarify the association between sedentary behavior and incident cancer.MethodPubMed and Embase databases were searched up to March 2014. All prospective cohort studies on the association between sedentary behavior and incident cancer were included. The summary relative risks (RRs) with 95% confidence intervals (CIs) were estimated using random effect model.ResultsA total of 17 prospective studies from 14 articles, including a total of 857,581 participants and 18,553 cases, were included in the analysis for sedentary behavior and risk of incident cancer. The overall meta-analysis suggested that sedentary behavior increased risk of cancer (RR = 1.20, 95%CI = 1.12–1.28), with no evidence of heterogeneity between studies (I 2 = 7.3%, P = 0.368). Subgroup analyses demonstrated that there were statistical associations between sedentary behavior and some cancer types (endometrial cancer: RR = 1.28, 95% CI = 1.08–1.53; colorectal cancer: RR = 1.30, 95%CI = 1.12–1.49; breast cancer: RR = 1.17, 95%CI = 1.03–1.33; lung cancer: RR = 1.27, 95%CI = 1.06–1.52). However, there was no association of sedentary behavior with ovarian cancer (RR = 1.26, 95%CI = 0.87–1.82), renal cell carcinoma (RR = 1.11, 95%CI = 0.87–1.41) or non-Hodgkin lymphoid neoplasms (RR = 1.09, 95%CI = 0.82–1.43).ConclusionThe present meta-analysis suggested that prolonged sedentary behavior was independently associated with an increased risk of incident endometrial, colorectal, breast, and lung cancers, but not with ovarian cancer, renal cell carcinoma or non-Hodgkin lymphoid neoplasms.
Highlights
Sedentary behavior is ubiquitous in modern adults’ daily lives [1]
Subgroup analyses demonstrated that there were statistical associations between sedentary behavior and some cancer types
There was no association of sedentary behavior with ovarian cancer (RR = 1.26, 95%confidence intervals (CIs) = 0.87–1.82), renal cell carcinoma (RR = 1.11, 95%CI = 0.87–1.41) or non-Hodgkin lymphoid neoplasms (RR = 1.09, 95%CI = 0.82–1.43)
Summary
Sedentary behavior is ubiquitous in modern adults’ daily lives [1]. It is defined as any waking behavior in a sitting or reclining posture, expending #1.5 times the resting energy demand (for example TV viewing, computer use, occupational sitting, reading, and sitting in a car) [2]. The time adults spend sedentary is relatively independent from their time spent in MVPA, for example, individuals may frequently participate in MVPA but still spend substantial amounts of their time sitting [3]. Sedentary behavior is ubiquitous in modern adults’ daily lives and it has been suggested to be associated with incident cancer. We performed a systematic review and metaanalysis of prospective cohort studies to clarify the association between sedentary behavior and incident cancer
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