Abstract
This study was to examine the sedative–hypnotic effect of YZG-330 and its influence on Cl− influx in mouse cortical cells. In a sleep time-prolongation test in which mice were administered a threshold dosage of sodium pentobarbital (ip), YZG-330 (0.125, 0.5 and 2mg/kg, po) prolonged the sleep time by 25% (P>0.05), 64% (P<0.01) and 506% (P<0.001), respectively. Thereafter, treatment with YZG-330 permitted mice that had woken up after the threshold dose of sodium pentobarbital (ip) to fall asleep again. A Cl−-sensitive fluorescent probe, N-(ethoxycarbonylmethyl)-methoxyquinolinium bromide (MQAE), was used to determine the effect of YZG-330 on Cl− influx. YZG-330 (0.3, 0.6 and 1.5mM) increased Cl− influx in mouse cortical cells in a concentration-dependent manner. These data suggest that YZG-330 has a hypnotic effect in mice, and the effect may be related to an increase in Cl− influx in cortical cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
