Abstract
Essential oils from fresh leaves of Eucalyptus urophylla (EOEU) and E. brassiana (EOEB), obtained by hydrodistillation, were orally administered to Swiss male mice 60 min before experimental procedures. EOEU and EOEB at either 200 or 400 mg/kg were evaluated for sedative/hypnotic activity through pentobarbital sleeping time, locomotor activity by open-field procedure, and anticonvulsant activity through seizures induced by pentylenetetrazole. EOEU and EOEB were effective in increasing the sleeping time, as well as diminishing ambulation in the open-field test. In addition, EOEU (but not EOEB) significantly increased the number of mice protected against PTZ-induced death. Our results are in accord with the ethnopharmacological use of Eucalyptus species, and, after complementary toxicological studies, could support further investigations to assess their use as sedative agents.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
