Abstract
Glinus oppositifolius is a small herb, widely used in the traditional medicine of Bangladesh in treatment of a variety of diseases and disorders such as insomnia, pain, inflammation, jaundice, and fever. The present study evaluated the sedative and anxiolytic potentials of the ethanol extract of leaves of G. oppositifolius (EEGO) in different behavioral models in mice. The sedative activity of EEGO was investigated using hole cross, open field, rotarod, and thiopental sodium- (TS-) induced sleeping time determination tests, where the elevated plus maze (EPM) and light-dark box (LDB) exploration tests were employed to justify the anxiolytic potentials in mice at the doses of 50, 100, and 200 mg/kg. The results demonstrated that EEGO significantly inhibited the exploratory behavior of the animals both in hole cross and in open field tests in a dose-dependent manner. It also decreased motor coordination and modified TS-mediated hypnosis in mice. In addition, EEGO showed anxiolytic potential by increasing the number and time of entries in the open arm of EPM, which is further strengthened by increase in total time spent in the light part of LDB. Therefore, this study suggests the sedative and anxiolytic properties of the leaves of G. oppositifolius and supports the traditional use of this plant in treatment of different psychiatric disorders including insomnia.
Highlights
Anxiety and insomnia are the most prevalent physiological and psychological states characterized by cognitive, emotional, and behavioral components affecting one-eighth of the world population [1]
The present study evaluated the effect of an ethanol extract of G. oppositifolius on CNS using several behavioral models in mice
Our results demonstrated that EEGO significantly (p < 0.01) reduced locomotion of the animals both in hole cross and in open field tests
Summary
Anxiety and insomnia are the most prevalent physiological and psychological states characterized by cognitive, emotional, and behavioral components affecting one-eighth of the world population [1]. Glinus oppositifolius (family: Molluginaceae) is a very common herb in Bangladesh, locally known as “gima shak.” This plant is extensively used by the local people as a vegetable and the traditional healers as an essential ingredient in treatment of a wide range of diseases and disorders including pain, inflammation, jaundice, diarrhea, boils, and malaria [4]. According to the aforementioned medicinal properties and the presence of different bioactive phytochemicals, researchers tried to validate its traditional uses against different diseases and disorders Their findings revealed that G. oppositifolius is effective as an antioxidant, hypoglycemic, Evidence-Based Complementary and Alternative Medicine anti-inflammatory [4], antidiarrheal, and anthelmintic [5] agent. This influenced us to design and conduct the present study to evaluate the impact of ethanol extract of leaves of G. oppositifolius in different behavioral models in mice
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