Sedation and analgesia effects of dexmedetomidine on multiple trauma patients with mechanical ventilation

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Objective To explore the sedation and analgesia effect of dexmedetomidine (DEX) in patients with multiple trauma during mechanical ventilation. Methods Eighty cases of multiple trauma patients under mechanical ventilation treated from September 2016 to March 2017 were analyzed by retrospective case-control study. There were 58 males and 22 females with an age range of 18-60 years (mean, 41.87 years). The injury severity score (ISS) was (18.45±4.53)points. The patients were treated with sedation and analgesia, and they were divided into two groups according to the sedative drugs. DEX composite tartaric acid butorphanol were used in 40 patients as DEX group. Midazolam composite tartaric acid butorphanol were used in 40 patients as Midazolam group. The degree of sedation score (Ramsay score) were compared between groups. The time from initial drug use to effective sedation achievement, daily wake-up time, mechanical ventilation duration, emergency intensive care unit (EICU) time, dosage of tartaric acid butorphanol, heart rate, blood pressure changes, and incidence of delirium were compared. Results (1) Two groups could both reach the target of sedation. DEX group had shorter daily wake-up time, shorter mechanical ventilation time and shorter length of EICU stay compared with Midazolam group (P 0.05). Conclusions For multiple trauma patients with mechanical ventilation, DEX can attain sedation and analgesia and shorten daily wake-up time, mechanical ventilation time, and length of hospital stay. DEX can reduce the dosage of analgesic (butorphanol) and the incidence of delirium. Blood pressure and heart rate are associated with small variations before and after sedation. Key words: Multiple trauma; Analgesia; Dexmedetomidine