Abstract
Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome
Highlights
Secular trends (STs) in birth parameters [1,2,3], growth [4, 5], and timing of puberty [6,7,8] are observed in normal populations in various settings
Spontaneous puberty onset increased from 15 to 30% (p < 0.001)
Mean age at the start of growth hormone (GH) treatment decreased from 10.8 to 7.4 years (−3.4 years; p < 0.001), and substantial declines were seen in ages at onset of spontaneous and induced puberty (−2.0 years; p < 0.001) and menarche (−2.1 years; p < 0.001)
Summary
Secular trends (STs) in birth parameters [1,2,3], growth [4, 5], and timing of puberty [6,7,8] are observed in normal populations in various settings. Turner syndrome (TS) is caused by structural abnormalities in or complete loss of an X chromosome. It affects approximately 1 in 2,500 live-born female girls. Whether children with chromosomal disorders of growth and puberty are affected by secular trends (STs) as observed in the general population remains unanswered, but this question has relevance for expectations of spontaneous development and treatment responses
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