Abstract
Dyslipidemia is a primary, critical risk factor for cardiovascular disease. Therefore, evaluating the trends in lipid profiles is crucial for the development of health policies and programs. We studied trends in lipid profiles in Korean adults over an 11-year period according to the use of lipid-lowering medications through age-specific analysis. A total of 73,890 participants were included in the Korean National Health and Nutrition Examination Survey III (2005)-VI (2013–2015). The proportion of participants on lipid-lowering medications has increased. This trend was apparent in age groups of over 40 years in both men and women. Lipid-lowering medications successfully reduced mean total cholesterol (TC), but there was no favorable trend in TC in participants not taking lipid-lowering medication in both men and women. Unlike men, triglyceride and non-high-density lipoprotein cholesterol (HDL) decreased in women without lipid-lowering medications. In age-specific hypercholesterolemia, the prevalence of hypercholesterolemia significantly increased in the age groups of 30–59 and 30–49 years in men and women without lipid-lowering medications, respectively. Meanwhile, mean HDL-C levels increased over the 11-year period regardless of lipid-lowering drug use in both men and women. These analyses identified an upward trend in TC and HDL-C over the 11-year period.
Highlights
According to the 2017 statistical update of the American Heart Association, the number of deaths from cardiovascular disease (CVD) has been decreasing since 2004 [1]
Our data revealed that total cholesterol (TC) and high-density lipoprotein cholesterol (HDL)-C level increased and the proportion of taking lipidlowering medications increased over the 11-year study period
Many clinical and epidemiologic studies have demonstrated that dyslipidemia is an important risk factor of CVD [6,18,19]
Summary
According to the 2017 statistical update of the American Heart Association, the number of deaths from cardiovascular disease (CVD) has been decreasing since 2004 [1]. There are several methods to prevent CVD, including smoking cessation, increased physical activity, and adoption of a healthy diet [3,4]. One recent study found that even moderate hyperlipidemia increases one’s risk of coronary heart disease (CHD) later in life, depending on the length of exposure [6]. Active screening and treatment of dyslipidemia are the first steps in prevention of CVD. Many countries have established public health programs to address dyslipidemia [7]. These efforts have successfully led to a decrease in the prevalence of
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