Abstract
This rare syndrome (F.P. Weber, 1925; H.A. Christian, 1928), undoubtedly represents a melange of different disorders of unknown pathogenesis, with similar clinical and pathologic manifestations. Relapsing febrile nonsuppurative nodular panniculitis is characterized by recurrent bouts of fever accompanied by the appearance of crops of small subcutaneous nodules, tender or painless, located chiefly on the trunk and extremities, especially the thighs, arms, and abdominal wall.<sup>1</sup>It is most often seen in adult women. Subsequent local subcutaneous atrophy occurs frequently. Fat necrosis in other sites has been reported, including the mesentery, breast, pericardium, retroperitoneal tissue, and bone marrow. The histopathologic changes are primarily limited to fat lobules, which show edema, fat necrosis, and cellular infiltration consisting chiefly of lymphocytes, plasma cells, and lipid-laden histiocytes. Many biopsy specimens show perivascular cuffing of inflammatory cells at the site of fat necrosis and endothelial proliferation of small vessels. The association of nodular panniculitis with
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