Secretory immunoglobulin A (SIgA) and dental caries of children with different diseases and conditions influencing oral medium

Abstract

SUMMARY SIgA is the main type immunoglobulin in the mixed saliva and is considered as the main secretion factor of the adaptive immunity in the mouth. The purpose of the study is an evaluation of the SIgA quantities and the connection of those antibodies with dental caries of children with different diseases and conditions influencing the oral medium. The study was performed with 116 children with diabetes, asthma, orthodontic problems (removable braces) and healthy controls. The following methods were used: (1) ELISA with “Salivary secretory IgA KIT of Salimetrics LLC USA; was used for quantitative determination of IgAS in the saliva ;(2) Evaluation of the liquid oral medium (test “Saliva check-GC”) and dental status (DMF-T) of the children studied. The results obtained came to show that 2/3 of the healthy children and the children with diabetes have low values of c( 300 µg/ml); There is no dependence between secretory immunity and dental caries in children.