Abstract
Transforming growth factor(TGF)‐ß activity was found in the neutral extracts of human myelogenous leukemic cells or K562 cells and the conditioned medium from K562 cell culture. BALB/c 3T3 cells grown in soft agar in the presence of TGF‐ß1 produced an activity that stimulated the growth of K562 cells. This activity was non‐dialyzable. acid‐stable, heat‐sensitive and partially Inactivated by pronase treatment. These results suggest a mutual growth reliance between the leukemic cells and fibroblasts mediated by paracrine growth factors produced by these cells.
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