Secretion of thiols and disulfide bond formation: retraction.

Abstract

In our report “Cysteine and glutathione secretion in response to protein disulfide bond formation in the ER” (12 Sept., [p. 1681][1]) ([1][2]), we describe data suggesting that cysteine and glutathione are secreted through the exocytic pathway in response to disulfide bond formation in the endoplasmic reticulum (ER). However, we have been unable to replicate some of the experiments conducted by the first author of that report. This calls into question our results and conclusions. We are now in the process of repeating most of the experiments, and are ready to communicate the available results on request. Meanwhile, we wish to alert readers that the original conclusion that cysteine and glutathione are secreted through the exocytic pathway is not supported unless further experimental evidence becomes available. We apologize for any difficulties that may have been experienced by the scientific community. 1. [↵][3]1. S. Carelli, 2. A. Ceriotti, 3. A. Cabibbo, 4. G. Fassina, 5. M. Ruvo, 6. R. Sitia , Science 277, 1681 (1997). [OpenUrl][4][Abstract/FREE Full Text][5] [1]: /lookup/doi/10.1126/science.277.5332.1681 [2]: #ref-1 [3]: #xref-ref-1-1 View reference 1 in text [4]: {openurl}?query=rft.jtitle%253DScience%26rft.stitle%253DScience%26rft.issn%253D0036-8075%26rft.aulast%253DCarelli%26rft.auinit1%253DS.%26rft.volume%253D277%26rft.issue%253D5332%26rft.spage%253D1681%26rft.epage%253D1684%26rft.atitle%253DCysteine%2Band%2BGlutathione%2BSecretion%2Bin%2BResponse%2Bto%2BProtein%2BDisulfide%2BBond%2BFormation%2Bin%2Bthe%2BER%26rft_id%253Dinfo%253Adoi%252F10.1126%252Fscience.277.5332.1681%26rft_id%253Dinfo%253Apmid%252F9287224%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [5]: /lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6Mzoic2NpIjtzOjU6InJlc2lkIjtzOjEzOiIyNzcvNTMzMi8xNjgxIjtzOjQ6ImF0b20iO3M6MjY6Ii9zY2kvMjc5LzUzNTUvMTI4My4xMC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=