Abstract
To determine whether peptides derived from the N-terminus of the corticotropin/melanotropin/endorphin precursor, pro-opiomelanocortin, are released into blood in response to acute haemorrhagic stress, we examined the effect of haemorrhage on plasma concentrations of immunoreactive γ 3-melanotropin, β-endorphin and cortisol. Plasma concentrations of immunoreactive γ 3-melanotropin (mean ± SEM) increased within 30 min of haemorrhage from 71.1 ± 10.4 to 106.8 ± 6.3 fmol/mL (p<0.01) and plasma cortisol increased from 16.2 ± 3.8 to 85.9 ± 22.4 pmol/mL (p<0.025). The changes in plasma immunoreactive γ 3-melanotropin and β-endorphin were positively correlated (p<0.025). This study shows that peptides derived from the N-terminus of pro-opiomelanocortin are co-secreted with the C-terminal peptide β-endorphin during acute haemorrhagic stress in sheep.
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