Abstract
Regenerative Medicine One of the main complications associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is the development of gastric ulcers. Proton-pump inhibitors are used to alleviate this condition; however, they are also associated with serious adverse events. Xia et al. developed a porcine model of NSAID-induced gastric ulcers and showed that intragastric administration of adipose tissue–derived mesenchymal stem cells rapidly promoted healing and reduced gastric inflammation. The therapeutic effect was mediated by activation of signaling pathways in ulcer tissue induced by stem cell–secreted factors. Mesenchymal stem cells or their secretome could be useful in treating NSAID-induced gastric ulcers. Sci. Transl. Med. 11 , eaat7455 (2019).
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