Abstract
A pancreatic acinar cell carcinoma was digested to single cells and the response of these cells to cholinergic and peptide secretagogues was studied. Dose response curves indicated that maximal stimulation was given by acetyl-choline (10-6mol/l), carbachol (3 x 10-5 mol/l), caerulein (10-9mol/l), bombesin (10-7mol/l), substance P (10-7mol/l), secretin (3 x 10-7mol/l) and VIP (10-6mol/l). Cholinergic stimulation was inhibited by atropine and stimulation by caerulein was inhibited by dibutyryl cyclic GMP. Our results show that single cells prepared from the tumour by collagenase digestion still retain these five functional receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
