Abstract
A new aliphatic acid, compound 1, together with six known metabolites, including nonactic acid (2), homononactic acid (3), ethyl homononactate (4), homononactylhomononactate (5), valinomycin (6), and cyclo-(Pro-Leu) (7), was isolated from the culture broth of Streptomyces sp. BM-8, an actinobacterial strain isolated from the feces of Equus quagga. The structures of these compounds were established by analyses of spectroscopic data, including 1D and 2D nuclear magnetic resonance spectra (NMR), as well as by HR-ESI-MS spectrometry and chemical derivative analyses. Additionally, a serial analogue of nonactic acid and homononacticacid (8–21) was synthesized. The cytotoxicity of 1–21 wastested against a panel of cancer cell lines, such as HT-29, MCF-7, A375 and K562, with MTT assay. In addition, the cytotoxicity tests revealed that 1 was less cytotoxic toward a panel of cancerous cells, as compared with valinomycin (6).
Highlights
A large number of drugs/leads were derived from microbial secondary metabolites that were isolated from microbes living in different environments all around the world [1]
The intestinal microbiota has proven to be a new source of bioactive molecules that are used for the treatment of different kinds of diseases [2]
The intestinal microbiota arecomposed of a large number of heterogeneous commensal bacterial species that have coevolved with the host for very long periods of time
Summary
A large number of drugs/leads were derived from microbial secondary metabolites that were isolated from microbes living in different environments all around the world [1]. The intestinal microbiota has proven to be a new source of bioactive molecules that are used for the treatment of different kinds of diseases [2]. It can be inferred that the metabolites produced by these microbials residing in the intestine might be safe and provide additional protection for their hosts’ homeostasis [3], and possess a strong potential for development as possible therapeutic agents [4], which has been supported by a lot of literature published in recent years. A large number of novel and bioactive metabolites associated with this special ecosystem have been identified [5,6,7]
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