Abstract
Chemical investigation of an extract of a soft coral, Nephthea sp. from the Bay of Bengal, showing antiviral activity against Ranikhet disease virus (in vitro) and Vaccina virus (in vitro and in vivo) afforded wax esters, cholesterol, 1-O-alkylglycerols, fatty acids and D(-)-2S,3R-2aminooctadeca-4E,8E-diene-1,3-diol-N-palmitate.
Highlights
A rich source of varied natural products[2] is found to be the soft corals that belong to the phylum Coelenterata (Cnidaria) comprised of marine invertebrates such as sea anemone, hydroids, corals, jelly fish and many other less distinguished animals
Chemical investigation of soft corals of the genus Nephthea[3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26] (i.e. N. chabrolii[3,4,5,6,7, 14], N. brassica,[8,15,16] N. tixera,[11] N. albida[11,12], N. erecta[13] and other Nephthea spp. 9,10,17-22) collected from various locations led to the isolation of varied extractives viz., sesquiterpenoids, tetraprenylbenzenoids[9,21], diphenylpropane-1,3-diol[10], sterols (24-methylenecholesterols11-16) and diterpenoids
Preliminary bioactivity studies involving CH2Cl2-MeOH (1:1) extract of the raw crushed organism showed antiviral activity against Ranikhet disease virus and Vaccina virus and found to have hypotensive activity in rats. This observation prompted the present investigators to take up systematic chemical investigations of the aforesaid marine organism, the results of which is being reported
Summary
A rich source of varied natural products[2] is found to be the soft corals that belong to the phylum Coelenterata (Cnidaria) comprised of marine invertebrates such as sea anemone, hydroids, corals, jelly fish and many other less distinguished animals. As a part of our search for bioactive components from marine sources a soft coral, Nephthea sp., was collected from the Bay of Bengal.
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