Abstract
The genus Lippia comprises approximately 200 species of herbs, shrubs and small trees, distributed throughout the South and Central America and tropical Africa. The species Lippia gracilis Schauer is an endemic aromatic plant of the Brazilian Northeast normally found in the states of Bahia, Sergipe and Piaui. The traditional communities of Caatinga, a semi-arid region of the Brazilian Northeast, use its leaves to treat throat and mouth infections, cutaneous diseases, ulcers, vagina disorders, acne, Pityriasis alba, dandruff, burns, wounds, sinusitis, bronchitis, nasal congestion, headache, jaundice and paralysis. Considering that the main investigations into the L. gracilis Schauer species are focused on its volatile constituents, in this report, we describe the isolation, by liquid chromatography with diode array detector-solid phase extraction/nuclear magnetic resonance (LC-DAD-SPE/NMR), of five flavonoids besides free and glycosidically bound carvacrol from an infusion of the leaves of a genotype of this species.
Highlights
Brazilian plants have a great potential to be explored because, for many of them, there is little or no knowledge of their chemical compositions.[1]
There is little knowledge about the non-volatile constituents of L. gracilis, there are several phytochemical studies describing the isolation of various compounds from other species of this genus, including iridoid glucosides, phenylethanoid glucosides, phenylpropanoids, triterpenes saponins, flavonoids, naphthoquinones, flavonoids glucosides, lignans, sesquiterpenes and triterpenes.[3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]
Previous chemical investigations into the L. gracilis Schauer species are focused on its volatile constituents where thymol and carvacrol, which showed strong antimicrobial activity against fungi and bacteria, are the main components.[12]
Summary
Brazilian plants have a great potential to be explored because, for many of them, there is little or no knowledge of their chemical compositions.[1]. The 1D and 2D NMR spectra of the isolated compounds were acquired at 299 K with the use of a Bruker Avance
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