Secondary Laparoscopic Cytoreduction in Recurrent Ovarian Cancer: A Large, Single-Institution Experience

Abstract

Study ObjectiveTo analyze the feasibility and safety of laparoscopic secondary cytoreductive surgery in a retrospective series of patients with platinum-sensitive recurrent ovarian cancer. DesignRetrospective cohort study (Canadian Task Force classification II-2). SettingCatholic University of the Sacred Heart, Rome, Italy. PatientsBetween October 2010 and October 2016, 58 patients with recurrent ovarian cancer were selected for a retrospective analysis of data. InterventionsAll patients underwent a laparoscopic secondary cytoreduction with single or multiple procedures. ResultsThe most frequent pattern of recurrence was peritoneal (48.3%); 6 patients (10.3%) experienced parenchymal disease (spleen, n = 5; liver, n = 1), and 24 patients (41.4%) had lymph node recurrence. Complete debulking was achieved in all patients. The median operative time was 204 minutes (range, 55–448 minutes), median estimated blood loss was 70 mL (range, 20–300 mL), and the median length of hospital stay was 4 days (range, 1–21 days). Four patients (6.8%) experienced intraoperative complications. Early postoperative complications were documented in 6 patients (10.3%), but only 1 G3 complication was noted. The median duration of follow-up since secondary cytoreduction was 24 months (range, 9–71 months). Twenty-one patients (36.2%) experienced a second disease relapse. The median progression-free survival (PFS) was 28 months, and the 2-year PFS was 58.7%. Five patients died (8.6%); the 2-year overall survival was 90.7%. ConclusionsFor selected patients, laparoscopy is a feasible and safe approach to optimal cytoreduction for patients with recurrent ovarian cancer.