Abstract
Calcitonin was administered to kittens for periods of 5–10 days; thereafter serial determinations of the serum calcium and phosphorus were made. Subsequently, groups of animals were nephrectomized or thy ropara thyroidectomized; the response to calcitonin was then measured. Calcitonin produced hypocalcemia and hypophosphatemia initially; resistance to the hypocalcemic effect soon developed and was associated with an increasing hypophosphatemic response. The hypophosphatemic response to calcitonin was abolished within 24 hr after nephrectomy or thyroparathyroidectomy. Thyroparathyroidectomy abolished the return to normocalcemia. The results suggest increased parathyroid activity. Autoradiography and tetracycline labeling showed that both endochondral and diaphyseal bone formation rates were suppressed; linear bone apposition rates correlated with the fall in serum phosphorus. Increased osteoclastic activity associated with bone resorption was probably a manifestation of increased parathyroid activity. The ...
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