Abstract
Hodgkin’s lymphoma (HL) is one of the most curable malignant diseases in adults. However, HL patients have a higher risk of developing second malignancies compared with the general population. The population of adult cancer survivors is growing, thus, the long-term effects of cancer treatment, including secondary cancer development, have become an increasingly important concern in the field of oncology. The current study presents the case of a female HL survivor who developed two secondary malignancies within 29 years of follow-up. Furthermore, a review of the literature was conducted, which focused on secondary breast and gastrointestinal cancers in HL survivors.
Highlights
Hodgkin's lymphoma (HL), which predominantly occurs in young and middle‐aged individuals, is one of the most curable malignant diseases in adults
The current study presents the case of an HL survivor who was treated for HL in 1985 and developed two secondary malignancies within 29 years of follow‐up
The increased occurrence of secondary malignancies was reported in HL and multiple myeloma survivors [7,8]
Summary
Hodgkin's lymphoma (HL), which predominantly occurs in young and middle‐aged individuals, is one of the most curable malignant diseases in adults. Immovable, ~4 cm in diameter lymph nodes in the left supraclavicular area. After completion of the chemotherapy regimen, the patient was irradiated in the supradiaphragmatic and paraaortic lymph node areas, and achieved complete remission. Subsequent histopathological examination determined an invasive, grade two, estrogen and progesterone receptor (ER and PR)‐positive (score 3+), HER2‐negative ductal carcinoma lesion of the breast (diameter, 2.5 cm) and metastasis to one of the axillary lymph nodes. A pathology report of the biopsied mass indicated adenocarcinoma, and chest and abdomen computed tomography (CT) scans revealed no distant metastasis. The pathology report indicated grade two metastatic tubular adenocarcinoma, which possibly corresponded to colorectal cancer metastasis; a positron emission tomography‐CT scan did not reveal any other metastatic lesions. Following surgery the patient received no systemic treatment and remains under surveillance
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