Abstract
Sclerosing encapsulating peritonitis (SEP), which is interchangeably used with the term ‘’abdominal cocoon syndrome’’, is a rare condition characterized by a thick fibrous membrane encasing portions of the intestinal wall leading to recurrent bowel obstructions. To date, literature describing the association between this condition and chronic beta-blocker therapy is scarce. This report adds by detailing a rare presentation of SEP and highlights an understudied yet important association of SEP with chronic beta-blocker therapy.
Highlights
Sclerosing encapsulating peritonitis (SEP) is characterized by a thick fibrous membrane encasing portions of the intestinal wall and presenting with recurrent bowel obstructions [1]. While this condition is often asymptomatic, patients may present with moderate-to-severe abdominal pain due to partial or complete bowel obstruction
SEP is a rare condition characterized by thick fibrous membranes covering most or all of the small and large bowels [1]
While the pathogenesis of Idiopathic SEP is poorly understood, studies suggest that the fibrosis occurs secondary to unregulated fibroblasts activity and cytokine release
Summary
Sclerosing encapsulating peritonitis (SEP) is characterized by a thick fibrous membrane encasing portions of the intestinal wall and presenting with recurrent bowel obstructions [1]. While this condition is often asymptomatic, patients may present with moderate-to-severe abdominal pain due to partial or complete bowel obstruction. Review of the previous medical records showed this patient to have a history of recurrent admissions for unremitting, diffuse abdominal pain. CT images from two years prior are shown in Figures 1, 2 During this admission, the patient’s bowel obstruction was managed conservatively. By day 5 of his hospital admission, imaging showed resolution of the obstruction
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