Abstract

Congenital malformations are a major cause of miscarriage, perinatal mortality, prematurity, childhood death and disability worldwide. The well-being of each affected child with a birth defect depends primarily on which organ or body part is affected and how severely. The World Health Organization (WHO) estimates that approximately 295,000 newborns die each year as a result of congenital anomalies during the neonatal period.[1] The development of research in this area, the early diagnosis of birth defects, the promotion of prenatal screening programs, and the development of preventive public health strategies are important tools with great impact on the prognosis of these defects. The most common birth defects are cardiac anomalies, neural tube defects and trisomy 21.[1] [2]

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