Abstract
Retinol (ROH) is an essential micronutrient required for normal fetal development and an essential molecule for antioxidant processes. To investigate the putative role of ROH as a marker of preeclampsia in early second trimester amniotic fluid (AF). Case-control study comparing the concentration of ROH and other antioxidants such as uric acid, vitamin E and malondialdehyde (MDA) in second trimester AF in patients that later developed preeclampsia with normal pregnancies. The concentration of ROH in amniotic fluids of women that later developed preeclampsia was significantly higher than those of uncomplicated pregnancies (66.72µg/l (49.00-70.56) vs. 44.4µg/l (31.9-51.17), p<0.05). No statistical significant difference was found in uric acid, vitamin E and MDA concentration. In the multivariate logistic regression, concentrations of ROH in amniotic fluids directly correlate with the risk of developing preeclampsia (OR 1.13, IC 0.01-1.26, p<0.05). Second trimester AF ROH concentration was significantly higher in pregnancies that developed preeclampsia compared to normal pregnancies.
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