Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature.

Jinchao Chen,Shaoxing Zhu,Nienie Qi,Hua Wang,Zongping Wang,Yedie He

doi:10.3389/fonc.2021.780130

Abstract

ObjectivesTo evaluate the nature, diagnosis, treatment and prognosis of second primary renal cell carcinoma (SPRCC).Materials and MethodsWe retrospectively collected data from 118 patients with SPRCC. Clinical characteristics, imaging features and treatments were analyzed and comparisons between SPRCC and renal metastases (RM) were made.ResultsSPRCC accounts for 11.4% of all RCC. The most common types of extrarenal malignancies included lung, colorectal, breast and gynecological cancers. The median age was 58.5 years old, and 61.0% (72/118) of the patients were male. About 5.1% of the patients presented with symptoms. The average tumor diameter was 4.4 cm (1-8.4 cm). The diagnostic specificity of enhanced computed tomography (CT) was 80.1%. When comparing with RM, more patients with stage I–II extrarenal malignancy and less patients with bilateral, multiple, and endogenic renal masses on computed tomography were found in the SPRCC group. A total of 110 SPRCC patients underwent surgery, including 48 radical nephrectomies and 62 partial nephrectomies. The median overall survival time was 117 months. Female, asymptomatic status, no distant metastasis, and surgical treatment predicted a better survival.ConclusionsSPRCC are not uncommon, and it should be considered during the follow-up of patients with nonrenal malignancy. The differential diagnosis between SPRCC and RM was mainly based on imaging and puncture biopsy.

Highlights

The second primary cancer (SPC) refers to the malignancy found at the same time with the primary cancer or later, which should exclude metastasis and recurrence [1]
Second Primary Renal Cell Carcinoma has resulted in a growing population of cancer survivors, and the incidence and mortality from SPC are likely to increase [3]
Second Primary Renal Cell Carcinoma (SPRCC) accounts for 11.4% of all RCC

Summary

Introduction

The second primary cancer (SPC) refers to the malignancy found at the same time with the primary cancer or later, which should exclude metastasis and recurrence [1]. SPC is one of the major prognostic factors among cancer survivors, and it is estimated to be the sixth most common form of malignancy worldwide [2]. The development of diagnostic and treatment technologies for cancer. Second Primary Renal Cell Carcinoma has resulted in a growing population of cancer survivors, and the incidence and mortality from SPC are likely to increase [3]. Second Primary Renal Cell Carcinoma (SPRCC) is a common type of SPC [5]. The nature of these special RCC, as well as their diagnosis, treatment and prognosis has not been described in detail. When faced with a renal mass in patients with nonrenal malignancy, the differential diagnosis of SPRCC from renal metastases was critical

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