Abstract
The cancer burden in the oldest old has increased rapidly. This study aimed to investigate the epidemiology of second primary malignancy (SPM) in malignant solid tumor survivors aged 85 years and older utilizing the Surveillance, Epidemiology, and End Results (SEER) database. A total of 128,466 malignant solid tumor patients had been identified between 2000 and 2011, including 6774 patients who developed a SPM. The overall crude incidence of developing a SPM was 5.3%. Considering death as a competing event, the 3, 5, and 10-year cumulative incidence was 1.9%, 3.2%, and 5.4%, respectively. Relative younger age, male gender, surgery history, local stage and first primary malignancy (FPM) site located in the urinary system were related to higher cumulative incidence. A median time interval of 24.0 months was found between diagnosis of FPM and SPM. The most common SPM site was digestive system, whereas the least common was oral cavity and pharynx. The median overall survival (OS) was 49.0 months, and the median survival after SPM was 13.0 months. Relative older age, male gender and black race were associated with worse OS and survival after SPM, as well as higher hazard ratios of death. In conclusions, this study performed a comprehensive analysis of SPM among malignant solid tumor survivors aged 85 years and older. Additional studies are needed to characterize the specific cancer type of interest.
Highlights
The cancer burden in the oldest old has increased rapidly
The present study aimed to investigate the epidemiology of all second primary malignancy (SPM) in patients with a malignant solid tumor as the first primary malignancy (FPM) and age equals to or greater than 85 years by utilizing the Surveillance, Epidemiology, and End Results (SEER) database
A total of 128,466 malignant solid tumor patients aged 85 years and older were identified from the SEER database between 2000 and 2011, including 6774 patients who developed a SPM
Summary
This study aimed to investigate the epidemiology of second primary malignancy (SPM) in malignant solid tumor survivors aged 85 years and older utilizing the Surveillance, Epidemiology, and End Results (SEER) database. This study performed a comprehensive analysis of SPM among malignant solid tumor survivors aged 85 years and older. Given the increased incidence and prolonged survival time, cancer survivors aged 85 years and older may suffer from a second primary malignancy (SPM). The present study aimed to investigate the epidemiology of all SPM in patients with a malignant solid tumor as the FPM and age equals to or greater than 85 years by utilizing the Surveillance, Epidemiology, and End Results (SEER) database. We tried to identify risk factors associated with cumulative incidence, overall survival (OS) and survival after developing a SPM
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