Abstract
BackgroundIn this retrospective study, data from patients listed in the Korea Central Cancer Registry during 1993–2014 were analysed, to investigate the incidence and survival of second primary cancers (SPCs) after a diagnosis of primary peritoneal, epithelial ovarian, and fallopian tubal (POFT) cancer.MethodsThe standardised incidence ratio (SIR) and survival outcomes of patients with SPCs among POFT cancer survivors were analysed.ResultsAmong 20,738 POFT cancer survivors, 798 (3.84%) developed SPCs, at an average interval of 5.50 years. SPC risk in POFT survivors (SIR, 1.29) was higher compared to the general population. The most high-risk type of SPC was leukaemia (3.07) followed by the lung and bronchus (1.80), colon (1.58), rectum and rectosigmoid junction (1.42), thyroid (1.34), and breast (1.26). In women aged < 60 years, cancer of the breast (1.30), ascending colon (2.26), and transverse colon (4.07) as SPCs increased. Up to 10 years after POFT cancer treatment, leukaemia risk increased, especially in those < 60 years, with serous histology, and with distant stage, which required aggressive chemotherapy. The median overall survival time was 12.8 years and 14.3 years in women with POFT cancer and SPCs, respectively. Thyroid and breast cancers were favourable prognostic markers among SPCs.ConclusionsThe overall SPC risk increases in POFT cancer survivors, especially in those < 60 years. The cancer risk of breast and the proximal colon increase based on hereditary predisposition, while leukaemia likely develops from aggressive treatment. The median overall survival is favourable in POFT cancer survivors with SPCs.
Highlights
In this retrospective study, data from patients listed in the Korea Central Cancer Registry during 1993– 2014 were analysed, to investigate the incidence and survival of second primary cancers (SPCs) after a diagnosis of primary peritoneal, epithelial ovarian, and fallopian tubal (POFT) cancer
The standardised incidence ratios (SIRs) and corresponding 95% confidence intervals (CIs) of SPC among POFT survivors were analysed to quantify the relative risk compared to women in the general population
The incidence of POFT diagnosis peaked during the ages 50–59 years (28.38%)
Summary
Data from patients listed in the Korea Central Cancer Registry during 1993– 2014 were analysed, to investigate the incidence and survival of second primary cancers (SPCs) after a diagnosis of primary peritoneal, epithelial ovarian, and fallopian tubal (POFT) cancer. The incidence of ovarian cancer has been continuously increasing, resulting in an annual percent change of + 1.5% during 1999–2010, with an estimated incidence of 2618 and mortality of 1168 in 2017 in Korea [2, 3]. Epithelial ovarian cancer is the same disease entity as primary peritoneal cancer (C48.2) and fallopian tubal cancer (C57). Primary peritoneal, epithelial ovarian, and fallopian tubal (POFT) cancers are diagnosed and treated in similar ways
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