Abstract
Eight children treated between 1977 and 1983 with the UK Children's Cancer Study Group's non-Hodgkin lymphoma (NHL) and T-cell protocols have developed second malignancies within 7 years of commencing treatment. Five developed acute non-lymphoblastic leukaemia and a sixth died from infection while pancytopenic with a pre-leukaemic marrow. The other malignancies were cerebral astrocytoma and an undifferentiated low grade sarcoma. These eight children were included among 261 children studied in the first UKCCSG NHL and T-cell trials giving an actuarial incidence of 7.8% second malignancy at 7 years. Six had received adjuvant radiotherapy which may have contributed to the high incidence of second malignancy.
Highlights
Three children treated with these protocols were reported to have developed acute myeloid leukaemia (Haworth et al, 1985; Rose et al, 1985; Darbyshire & Mott, 1986)
The child described in case 7 had severe neutropenia for several months and marrows taken during this time showed evolution towards M4 myeloid leukaemia
This paper describes a relatively high incidence of secondary myeloid leukaemia in a group of children with nonHodgkin lymphoma (NHL)
Summary
Three children treated with these protocols were reported to have developed acute myeloid leukaemia (Haworth et al, 1985; Rose et al, 1985; Darbyshire & Mott, 1986). We report 3 additional patients with acute leukaemia or pre-leukaemia and 2 other cases of second malignancy viz: cerebral astrocytoma and undifferentiated sarcoma. A Kaplan-Meier estimate of the risk of second malignancy is derived for these 8 patients
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