Abstract
PurposeIt is of obvious interest to identify clinical prognosis-related oncogenes in HNSCC (head and neck squamous cell carcinoma).MethodsBased on the available datasets within the TCGA (The Cancer Genome Atlas) and the GEO (Gene Expression Omnibus) databases, the potential mechanism of action of the SEC61G (SEC61 translocon subunit gamma) gene in HNSCC tumorigenesis was explored by several bioinformatics approaches.ResultsThere was a higher expression level of SEC61G in primary HNSCC tumor tissues than in normal tissues. Moreover, highly expressed SEC61G was statistically associated with the poor survival prognosis of HNSCC patients. When HPV (human papilloma virus) was considered, we also observed a relatively lower proportion of “arm-level gain” and “high amplification” types of CNA (copy-number alteration) in the HNSCC-HPV (+) group than in the HNSCC-HPV (−) group. Additionally, we identified SEC61G CAN-correlated genes, such as CCT6A (chaperonin-containing TCP1 subunit 6A) and HUS1 (HUS1 checkpoint clamp component), and found a correlation between SEC61G copy-number segments and prognosis related to overall and progression-free survival intervals of HNSCC patients. Moreover, the molecular regulation mechanisms of the spliceosome, ribosome, proteasome degradation, cell adhesion, and immune infiltration of B and CD8+ T cells may contribute to the involvement of SEC61G in the pathogenesis of HNSCC.ConclusionsThe SEC61G gene was identified for the first time as a prognostic biomarker of HNSCC. The detailed underlying mechanism merits further research.
Highlights
SEC61G is the main member of the Sec61 complex, which is a transmembrane channel across which proteins are translocated and integrated into the ER membrane [1, 2]
We studied the association between SEC61G expression and CNA across all TCGA cancers using the “sCNA” module of TIMER2.0
We first compared the differential expression of SEC61G between normal tissues and HNSCC tissues using two factors (HPV and sex)
Summary
SEC61G is the main member of the Sec complex, which is a transmembrane channel across which proteins are translocated and integrated into the ER (endoplasmic reticulum) membrane [1, 2]. Several publications have reported the correlation between SEC61G expression and the pathogenesis of certain cancers and the prognosis of patients with these cancers. The SEC61G-EGFR fusion gene was detected in the MI (mitogen-independent) stem-like cells of pediatric ependymomas [7]. It was reported that high expression of the SEC61G gene was correlated with a poor prognosis of glioblastoma patients in a study that used the TCGA and CGGA (Chinese Glioma Genome Atlas) datasets [8].
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