Abstract
A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. This report describes a case of a patient with hypoinsulinemic hypoglycemia and Leser-Trélat sign associated with a malignant solitary fibrous tumor with IGF2 secretion. Both conditions have improved after tumor excision.
Highlights
Cutaneous morphology can be modified by endocrine and metabolic diseases and skin lesions might serve as a window to the early diagnosis and treatment of various hormone-secreting tumors [1]
An example is a sudden eruption of multiple seborrheic keratosis called as LeserTrélat sign and it is more associated with adenocarcinomas it may be related to other tumors indicating worse prognosis [2]
Other tumors unrelated to β cell may cause hypoinsulinemic hypoglycemia by producing insulin growth factor-2 (IGF2) or its precursor named as big-IGF2 [3,4,5,6,7]
Summary
Cutaneous morphology can be modified by endocrine and metabolic diseases and skin lesions might serve as a window to the early diagnosis and treatment of various hormone-secreting tumors [1]. Other tumors unrelated to β cell may cause hypoinsulinemic hypoglycemia by producing insulin growth factor-2 (IGF2) or its precursor named as big-IGF2 [3,4,5,6,7]. Doege-Potter syndrome is a paraneoplastic hypoglycemia caused by solitary fibrous tumor [8, 9]. By out-patient clinic appointment he referred no hypoglycemic episodes and his acromegaloid features and cutaneous lesions shown an involution (Fig. 1b).
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