Abstract
BackgroundSebaceous carcinoma (SC) is frequently classified as periocular or extraocular. Extraocular SC is rare and mainly occurs in the head and neck, the major salivary glands, or oral mucosa. SC of the breast, lung, and ovary is particularly rare, and the few cases of SC of the breast predominantly exhibit intraductal growth.Case presentationA 47-year-old Japanese woman was referred to our hospital with accumulated polymorphic calcification in the left breast which was detected using mammography. Ultrasonography revealed an irregular 13-mm mass in the left breast, and analysis of a core needle biopsy revealed noninvasive ductal carcinoma. Total mastectomy and sentinel lymph node biopsy were performed. Histopathology demonstrated that carcinoma in situ (CIS) represented a significant lesion, and the cytoplasm of tumor cells was clear with numerous minute vacuoles. Immunohistochemical analysis demonstrated that most tumor cells expressed adipophilin. Together, these findings led to a diagnosis of SC, mainly comprising CIS.ConclusionsWe encountered a rare case of SC of the breast with predominant CIS.
Highlights
Sebaceous carcinoma (SC) is frequently classified as periocular or extraocular
We encountered a rare case of SC of the breast with predominant carcinoma in situ (CIS)
SC is characterized by lobular forms or nests of tumor cells that exhibit sebaceous differentiation, which distinguishes SC from invasive ductal carcinoma (IDC) [11]
Summary
Sebaceous carcinoma (SC) is frequently classified as periocular or extraocular [1]. Extraocular SC is rare, occurring mainly in the head and neck, major salivary glands, oral mucosa, breasts, lungs, and ovaries [2,3,4,5,6]. Carcinoma in situ (CIS) lesions of SC are rare, associated with extraocular SC, they occur in the head, neck, and upper arm [7,8,9,10]. We are unaware of reports of SC of the breast with predominant CIS. Mammography revealed a clustered pleomorphic calcification in the left C region (Fig. 1a–d). She was referred to our hospital for further examinations. Immunohistochemical analysis revealed that 50 to 90% of the tumor cells expressed adipophilin (Fig. 5d, e), leading to a diagnosis of SC of the breast. Together, these findings were consistent with pathological T1mi, N0, M0 Stage I. Metastasis or recurrence was not observed 16 months after surgery
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