Abstract
The review presents materials describing the seaweed-derived sulfated polysaccharides (SPS) as potential means for prevention and treatment of viral diseases of the respiratory tract, mainly influenza and COVID-19. The literature materials on the pathogenetic targets of influenza viruses and SARS-CoV-2, on the antiviral potential of SPS derived from red, brown and green algae, as well as on the mechanisms of antiviral action of these unique compounds are summarized. Seaweed SPS are characterized by high antiviral activity, good solubility, and almost complete absence of toxicity. Pathogens of respiratory infections do not form resistance under the SPS influence. The abovementioned facts allow us to consider these compounds as promising candidates for the creation of medicines, dietary supplements, and functional food products with antiviral and, above all, anti-influenza and anti-coronavirus activity on their basis in the future.
Highlights
ОБЗОРЫ compounds as promising candidates for the creation of medicines, dietary supplements, and functional food products with antiviral and, above all, anti-influenza and anti-coronavirus activity on their basis in the future
Seaweed sulfated polysaccharides (SPS) are characterized by high antiviral activity, good solubility, and almost complete absence of toxicity
Доля эпидемических коронавирусов в России в эпидемический сезон с октября 2018 г. по апрель 2019 г. среди лабораторно диагностированных случаев ОРВИ составляла 4,6–9,4% [15]
Summary
ОБЗОРЫ compounds as promising candidates for the creation of medicines, dietary supplements, and functional food products with antiviral and, above all, anti-influenza and anti-coronavirus activity on their basis in the future. В настоящей работе действие полисахаридов морских водорослей представлено в отношении основных социально значимых в настоящее время возбудителей ОРВИ — SARS-CoV-2 и вирусов гриппа. Результаты показали, что как исходный полисахарид, так и его сульфатированные производные эффективно дозозависимо ингибировали размножение вируса гриппа А в клетках MDCK.
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