Abstract
The present study aimed to investigate the influence of seasonality from different collection periods on the chemical composition and antifungal activity of the Psidium myrtoides O. Berg essential oil (OEFPm). The OEFPm chemical composition was evaluated through gas chromatography coupled to mass spectrometry (GC/MS). The oil's antifungal activity against species from the Candida genus, in isolation and in combination with Fluconazole at a subinhibitory concentration (MFC/16), was evaluated using the broth microdilution method, while its effect on Candida albicans pleomorphism was evaluated by microculture. The results showed the compound 1–8 cineol was the major component in all the samples. The OEFPm showed significant MFC ranging from 1,024 to ≥ 16,384 μg/mL for the C. albicans, C. krusei and C. tropicalis strains with IC50 values ranging from 103.3 to 3564.5 μg/mL. The essential oils affected morphological transition at all tested concentrations in the C. albicans morphological alteration assays. The results from this study show the collection period affected the chemical composition and the antimicrobial activity of the essential oil. A significant variation was documented for most chemical components and the biological activity of the seasonally collected samples, in addition to variations in morphological transition inhibition, an important virulence factor for the genus.
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