Abstract
Introduction :The pathogenesis of congenital diaphragmatic hernia (CDH) is not clear. Risk factors including environmental factors have been implicated in the pathogenesis of few congenital anomalies. We aimed to assess the effect of season on the incidence of CDH and mortality rate in the southwest of Iran.Material and Methods :In this retrospective study, the records of 60 patients with CDH who were admitted at Neonatal Intensive Care Unit (NICU) of Imam Khomeini Hospital of Ahvaz, Iran were evaluated.Results :Assuming that all the neonates born with CDH in the region reach this hospital, overall CDH prevalence rate was 1.09 per 10 000 total births. Conceptions in spring and summer in this region had statistically significantly higher incidence of CDH. Survival rate in the series was 41.6%.Conclusion :Seasonal variation has impact on the incidence of CDH. Mortality rate in neonates with CDH is still very high.
Highlights
The pathogenesis of congenital diaphragmatic hernia (CDH) is not clear
Congenital Diaphragmatic Hernia (CDH) is a malformation of the diaphragm, that secondary to persistence of a defect in the diaphragm, the abdominal contents protrude into the thoracic cavity [1]
Of the 548052 live births over the 5-year-period in the Khuzestan province, 60 neonates with confirmed diagnosis of CDH were admitted at Neonatal Intensive Care Unit (NICU) of Imam Khomeini Hospital of Ahvaz
Summary
The pathogenesis of congenital diaphragmatic hernia (CDH) is not clear. Risk factors including environmental factors have been implicated in the pathogenesis of few congenital anomalies. Congenital Diaphragmatic Hernia (CDH) is a malformation of the diaphragm, that secondary to persistence of a defect in the diaphragm, the abdominal contents protrude into the thoracic cavity [1]. Development of the diaphragm starts during the 4th week of gestation and completed by 8th weeks. In the fetuses with CDH, the diaphragm doesn't close completely during this period [2]. The prevalence of CDH is reported to be from 2.4 to 4.9 per 10000 births The pathogenesis and etiology of CDH is complex and remains poorly understood. Nitrofen and retinoids has been known to induce CDH in animal models [5,6,7,8,9]. Genetics probably plays a role [12]
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