Abstract
ObjectiveSeasonal variations in body composition and parameters that reflect nutritional status are well established in patients on hemodialysis (HD). However, to our knowledge, no study has assessed the changes in oxidative stress (OS). The aims of this study were to assess seasonal variations in OS, body composition, and other nutritional parameters. MethodsSeasonal variations in fat tissue mass (FTM), fat tissue index (FTI), adipose tissue mass (ATM), lean tissue mass (LTM), lean tissue index (LTI), body cell mass (BCM), overhydration (OH) volume, and OS (blood levels of derivatives of reactive oxygen metabolites [d-ROMs], thiobarbituric reactive substances, plasma protein reduced thiol content [THIOLS], and ferric reducing ability of plasma) were assessed in 45 patients on HD, 70 y of age (60.5–76.5 y). ResultsFTM (P < 0.001), FTI (P < 0.001), and ATM (P < 0.001) significantly increased, whereas LTI (P < 0.001), LTM (P < 0.001), BCM (P < 0.001), and OH volume (P = 0.004) significantly decreased over the season. Additionally, significant seasonal variations in the levels of d-ROMs (P = 0.02) and THIOLS (P = 0.02) were found. Levels of d-ROMs were found to be a significant predictor of LTM and BCM (β = –0.57; 95% confidence interval [CI], –1.08 to –0.06; P = 0.03; β = –0.04; 95% CI, –0.075 to –0.006; P = 0.02). Furthermore, hip circumference was found to be the most significant predictor of the level of d-ROMs (β = 2.66; 95% CI; 0.28–5.04; P = 0.03) and waist-to-height ratio (β = 251; 95% CI, 16.6–477.2; P = 0.03) and serum prealbumin levels of THIOLS (β = 263; 95% CI, 6.8–521.1; P = 0.04). ConclusionThese results suggest seasonal variations in OS in patients on HD and a possible interaction between OS and nutritional status in these patients.
Highlights
Seasonal variations in body composition and parameters that reflect nutritional status are well established in haemodialysis (HD) patients
Seasonal variations in fat tissue mass (FTM), fat tissue index (FTI), adipose tissue mass (ATM), lean tissue mass (LTM), lean tissue index, body cell mass (BCM and overhydration (OH), oxidative stress (OS) (the blood levels of derivatives of reactive oxygen metabolites (d-ROMs), thiobarbituric reactive substances (TBARS), plasma protein reduced thiol content (THIOLS) and ferric reducing ability of plasma (FRAP) were measured) and other nutritional parameters were assessed in 45 HD patients aged 70 (60.5-76.5) years
Statistically most significant predictor of d-ROM was hip circumference (β =2.66; P=0.03), while for THIOLS it was waist-to-height ratio (WHtR) (β=251(95% CI 16.6 to 477.2); P=0.03) and serum prealbumin level (β=263; P=0.04)
Summary
The objectives of our study were to assess seasonal variations in OS, body composition and other nutritional parameters, as well as their interactions. Considering the importance of OS and malnutrition in this population of patients the aim of this study was to define more precisely the seasonal variation of OS, body composition, anthropometry and laboratory parameters that reflect nutritional status in maintenance HD patients living in Dalmatia, South Croatia, as well as their interaction
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