Abstract
The susceptibility to endotoxin intoxication in rabbits was found to undergo a marked seasonal variation, being increased in winter and the least in summer. The activation of thyroid gland in winter was found to be related to the intense dyspneic response due to epinephrine discharge in this season. However, the characteristic metabolic derangements, such as the depletion of the liver glycogen especially pronounced in winter, was shown to be independent from it and seemed to be related to the enhanced hepatic metabolism in cold adaptation.Concerning the summer non-susceptibility, besides the lessening of the above potentiating factors, an assumption of some central alterations in reducing the disturbances in the autonomic nervous system in relation to the activation of the febrile mechanism seemed to be necessary.
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